Paraoxonase 1 activities and polymorphisms in autism spectrum disorders
نویسندگان
چکیده
منابع مشابه
Paraoxonase 1 activities and polymorphisms in autism spectrum disorders
Autism spectrum disorders (ASD) comprise a complex and heterogeneous group of conditions of unknown aetiology, characterized by significant disturbances in social, communicative and behavioural functioning. Recent studies suggested a possible implication of the high-density lipoprotein associated esterase/lactonase paraoxonase 1 (PON1) in ASD. In the present study, we aimed at investigating the...
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Background: Transforming growth factor-β1 (TGF-β1) has been found to play a crucial role in early central nervous system development. Several studies have illustrated decreased TGF-β1 levels in sera and brains of autistic children. Two point mutations in the TGF-β1 signal peptide at 869T/C and 915G/C have been reported to influence TGF-β1 expression. The aim of the pres...
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Paraoxonase 1 (PON1), an antioxidant enzyme closely associated with HDL (high-density lipoproteins), preserves LDL (low-density lipoproteins) against oxidation. Less protection may be therefore supposed by decreased PON1 activity. This study was undertaken to investigate the association of PON1 gene polymorphisms with diabetic angiopathy and to evaluate the relationship of these polymorphisms w...
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Objective: The present study has been carried out to compare the social competence in two groups of students with Autism Disorder (AD) and Learning Disorders (LD). Methods: This research was a kind of descriptive research with 2 comparative groups. 90 learning and Autistic disorder students aged 10 to 13 years (45 LD & 45 AD) were selected randomly as a statistical sample. For the assessment...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2008
ISSN: 1582-1838,1582-4934
DOI: 10.1111/j.1582-4934.2008.00414.x